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Match the description with the type of receptor model. -G-protein


A) nuclear receptor model
B) membrane-bound receptor model

C) A) and B)
D) undefined

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Which pattern of hormone secretion,often observed in steroid reproductive hormones,will fluctuate over a monthly cycle?


A) acute hormone secretion
B) episodic hormone secretion
C) long-term hormone secretion
D) chronic hormone secretion

E) B) and C)
F) A) and D)

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Match the description with the type of receptor model. -receptor molecule interacts with DNA


A) nuclear receptor model
B) membrane-bound receptor model

C) A) and B)
D) undefined

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How do most water-soluble hormones travel in the bloodstream?


A) attached to proteins
B) attached to carbohydrates
C) attached to amino acids
D) as free hormones

E) C) and D)
F) A) and B)

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D

Parathyroid hormone is released when blood calcium levels decrease.This is an example of control by __________ stimuli.


A) hormonal
B) neural
C) humoral
D) visceral

E) All of the above
F) None of the above

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Most hormones are regulated by


A) negative-feedback mechanisms.
B) neural-feedback mechanisms.
C) positive-feedback mechanisms.
D) hormonal-feedback mechanisms.

E) All of the above
F) A) and B)

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A

The role of cAMP when it acts as an intracellular mediator in cells is to


A) bind to and activate protein kinase.
B) activate genes in the nucleus to produce mRNA.
C) directly activate structural enzymes in the cytoplasm of the target cell.
D) catalyze a cascade reaction that ultimately activates genes on the DNA.
E) control levels of calcium in the cell.

F) A) and C)
G) A) and B)

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Once a lipid-soluble hormone is conjugated in the liver


A) its half-life is increased.
B) it can be more quickly eliminated from the body.
C) it can be stored for later use.
D) it is actively transported into cells.
E) it is more slowly eliminated from the body.

F) C) and E)
G) A) and E)

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Consider the following events in the nuclear receptor model: (1) Hormone receptor complex binds to DNA. (2) Messenger RNA directs synthesis of specific proteins. (3) Hormone binds to receptors in the nucleus (sometimes in the cytoplasm) (4) Messenger RNA synthesis is activated. (5) Synthesized proteins produce the response of the cell. Which of these events occurs in the nucleus?


A) 1,3,5
B) 1,3,4
C) 1,2,3
D) 3,4,5
E) All events occur in the nucleus.

F) A) and B)
G) B) and C)

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Which of the following statements regarding hormone transport and distribution is FALSE?


A) Only free hormones can diffuse through capillary walls and bind to target tissues.
B) Hormones can be transported free in the plasma or bound to plasma proteins.
C) Plasma protein concentration has no influence on free hormone concentration.
D) Hormones bind only to certain types of plasma proteins.
E) All of the statements are true.

F) A) and B)
G) A) and C)

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Match the chemical signal with the appropriate description. -neurotransmitter


A) chemicals produced by neurons that function as hormones
B) chemicals that act locally on nearby cells
C) chemical secreted by presynaptic terminal
D) influences same cell type from which it is secreted
E) chemical secreted into blood by specialized cells; travels some distance to target tissues

F) A) and E)
G) None of the above

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What type of chemical messenger will act locally on nearby cells?


A) paracrine
B) neurotransmitter
C) autocrine
D) endocrine

E) All of the above
F) B) and C)

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Members of which group of hormones are made from cholesterol?


A) amino acid derivatives
B) peptides
C) proteins
D) steroids

E) None of the above
F) A) and B)

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What do all hormones have in common?


A) They are made from amino acids.
B) They are bound to transport molecules in the blood.
C) They bind to and interact with a receptor on or in the target cell.
D) They use the second messenger mechanism to control the target cell.
E) They are all lipid-soluble.

F) D) and E)
G) None of the above

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Which of the following is a regulatory protein associated with membrane-bound receptor molecules?


A) ATP
B) calcium
C) M protein
D) G protein
E) DNA

F) B) and D)
G) A) and B)

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The endocrine system


A) releases neurotransmitters into ducts.
B) secretes chemicals that reach their targets through the bloodstream.
C) communicates via frequency-modulated signals.
D) contains organs called exocrine glands.
E) is isolated from the nervous system.

F) A) and E)
G) A) and D)

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When a hormone binds to a membrane-bound receptor,


A) membrane channels are destroyed.
B) cyclic GMP might be produced to act as an intracellular mediator.
C) the nucleus is phosphorylated to prevent G-protein activation.
D) messenger RNA is formed.
E) cellular DNA is altered.

F) A) and D)
G) C) and D)

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Hormone receptor molecules may be ____ in order to change the target cell's sensitivity to a given hormone.


A) increased in number
B) decreased in number
C) chemically altered
D) moved
E) increased in number,decreased in number and chemically altered

F) C) and D)
G) A) and C)

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Increasing levels of thyroid hormones decrease TSH levels.This is an example of _______ feedback.

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negative

Receptors for most water-soluble hormones are located


A) in the cytoplasm of their target cells.
B) on the plasma membrane of their target cells.
C) in the lysosomes of their target cells.
D) on the nuclear membrane of their target cells.
E) on the endoplasmic reticulum of their target cells.

F) B) and E)
G) A) and B)

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