Question 1

Which organ contains anatomical barriers that limit some drugs from gaining access?

Accepted Answer

A)  Kidney
B)  Liver
C)  Brain
D)  HeartE) A) and B)
F) A) and C)

Question 2

Drug metabolism can be affected by which factors? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

Accepted Answer

A)  Kidney disease
B)  Age
C)  Liver disease
D)  GeneticsE) A) and B)
F) All of the above

Question 3

Which method of drug excretion excretes most drugs in their original,unmetabolized form?

Accepted Answer

A)  Exhalation
B)  Defecation
C)  Sweating
D)  UrinationE) B) and C)
F) A) and D)

Question 4

First-pass effect can result in a large fraction of an administered drug being metabolically deactivated.Which client factors will decrease the magnitude of the first-pass effect? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

Accepted Answer

A)  Elderly client
B)  Hepatic disease
C)  Gallbladder disease
D)  Renal disease
E)  Parenteral medication administrationF) B) and E)
G) A) and E)

Question 5

Which factors influence the effectiveness of drug therapy? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

Accepted Answer

A)  Food-drug interactions
B)  Excretion rate
C)  Concentration of drug
D)  GenderE) A) and B)
F) All of the above

Question 6

What factors can affect drug absorption? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

Accepted Answer

A)  Blood pressure
B)  Laboratory values
C)  Heart rate
D)  WeightE) C) and D)
F) None of the above

Question 7

Drug A produces a certain therapeutic effect at a dose of 5 mg/kg.Drug B produces the same magnitude of effect at a dose of 0.1 mg/kg.How would the nurse describe the action of Drug A when compared to Drug B?

Accepted Answer

A)  Drug A is more efficacious.
B)  Drug A is less efficacious.
C)  Drug A is more potent.
D)  Drug A is less potent.E) C) and D)
F) All of the above

Question 8

What is the first step in drug transport?

Accepted Answer

A)  Metabolism
B)  Distribution
C)  Excretion
D)  AbsorptionE) A) and D)
F) A) and C) D

Question 9

A client takes two medications at the same time.Why might the action of one drug be intensified when this occurs?

Accepted Answer

A)  Neither drug will bind to any plasma protein receptors,and the effect of the more potent drug will be intensified.
B)  A client must never take two medications at the same time.
C)  The drugs bind together,and the effect of the more potent drug is intensified.
D)  Both drugs compete for the plasma protein receptors,and one drug will displace the other.E) A) and B)
F) B) and C)

Question 10

Which definition describes a receptor?

Accepted Answer

A)  A cell component to which a drug binds in a dose-dependent manner
B)  Present only in the drug's target tissue
C)  Required to drug action
D)  Analogous to the "key" in the lock-and-key model of drug-receptor interactionE) A) and B)
F) B) and C)

Question 11

Codeine has a greater maximal ability to suppress cough when compared with dextromethorphan.What is the most appropriate description of codeine when compared to dextromethorphan?

Accepted Answer

A)  Codeine is more efficacious.
B)  Codeine is less potent.
C)  Codeine is more potent.
D)  Codeine is less efficacious.E) B) and D)
F) A) and B)

Question 12

A client asks the nurse how medication is excreted from the body.Which response by the nurse is most appropriate?

Accepted Answer

A)  The lungs are the main organ of excretion.
B)  The kidney is the main organ of excretion.
C)  The colon is the main organ of excretion.
D)  The liver is the main organ of excretion.E) B) and C)
F) A) and B)

Question 13

What occurs when a medication binds to a plasma protein?

Accepted Answer

A)  The drug is working at its full potential.
B)  The drug is in the process of being excreted by the body.
C)  The drug is unable to reach its target cells.
D)  The drug has reached its target cells.E) A) and B)
F) B) and C)

Question 14

A student nurse asks the charge nurse the definition of a prodrug.What is the best response by the charge nurse?

Accepted Answer

A)  A prodrug is a brand name drug.
B)  A prodrug is not absorbed by the body.
C)  A prodrug is the first drug developed in a drug class.
D)  A prodrug requires metabolism to make it active.E) B) and C)
F) A) and D)

Question 15

A nurse is conducting an in-service for students regarding drug excretion.Which responses by the students indicate an understanding where drug excretion occurs? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

Accepted Answer

A)  Breast milk
B)  Urine
C)  Gastric juice
D)  Feces
E)  LungsF) B) and C)
G) D) and E)

Question 16

The nurse educator is describing the process by which drugs are transported after they have been absorbed or administered directly into the bloodstream.Which response by the student indicates understanding of the process?

Accepted Answer

A)  This process is metabolism.
B)  This process is administration.
C)  This process is excretion.
D)  This process is distribution.E) B) and C)
F) All of the above

Question 17

Which action will slow the absorption of a drug?

Accepted Answer

A)  Taking medication earlier than prescribed
B)  Taking medication with food
C)  Taking medication with water
D)  Taking medication before exerciseE) B) and C)
F) A) and B) B

Question 18

A nurse educator is teaching pharmacokinetics to the pharmacology class.What statement,made by a student,would show the class understands this term?

Accepted Answer

A)  "Pharmacokinetics describes how the body absorbs,distributes,metabolizes,and excretes drugs."
B)  "Pharmacokinetics is how drugs activate specific receptors."
C)  "Pharmacokinetics is what a drug does to the body."
D)  "Pharmacokinetics is the efficacy of a drug."E) A) and B)
F) A) and C)

Question 19

What is an indicator of how long a drug will produce its effect in the body?

Accepted Answer

A)  Potency
B)  Bioavailability
C)  Half-life (t1/2) 
D)  EfficacyE) A) and C)
F) A) and B)

Question 20

What is not a barrier to distribution of medications?

Accepted Answer

A)  Blood-brain barrier
B)  Blood-testicular barrier
C)  Blood-placental barrier
D)  Blood-lung barrierE) A) and D)
F) None of the above D

Exam 4: What Happens After a Drug Has Been Administered

Which organ contains anatomical barriers that limit some drugs from gaining access?

Correct AnswerverifiedShow Answer

Drug metabolism can be affected by which factors? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

Correct AnswerverifiedShow Answer

Which method of drug excretion excretes most drugs in their original,unmetabolized form?

Correct AnswerverifiedShow Answer

First-pass effect can result in a large fraction of an administered drug being metabolically deactivated.Which client factors will decrease the magnitude of the first-pass effect? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

Correct AnswerverifiedShow Answer

Which factors influence the effectiveness of drug therapy? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

Correct AnswerverifiedShow Answer

What factors can affect drug absorption? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

Correct AnswerverifiedShow Answer

Drug A produces a certain therapeutic effect at a dose of 5 mg/kg.Drug B produces the same magnitude of effect at a dose of 0.1 mg/kg.How would the nurse describe the action of Drug A when compared to Drug B?

Correct AnswerverifiedShow Answer

What is the first step in drug transport?

Correct AnswerverifiedD

A client takes two medications at the same time.Why might the action of one drug be intensified when this occurs?

Correct AnswerverifiedShow Answer

Which definition describes a receptor?

Correct AnswerverifiedShow Answer

Codeine has a greater maximal ability to suppress cough when compared with dextromethorphan.What is the most appropriate description of codeine when compared to dextromethorphan?

Correct AnswerverifiedShow Answer

A client asks the nurse how medication is excreted from the body.Which response by the nurse is most appropriate?

Correct AnswerverifiedShow Answer

What occurs when a medication binds to a plasma protein?

Correct AnswerverifiedShow Answer

A student nurse asks the charge nurse the definition of a prodrug.What is the best response by the charge nurse?

Correct AnswerverifiedShow Answer

A nurse is conducting an in-service for students regarding drug excretion.Which responses by the students indicate an understanding where drug excretion occurs? (Select all that apply.) Note: Credit will be given only if all correct choices and no incorrect choices are selected.

Correct AnswerverifiedShow Answer

The nurse educator is describing the process by which drugs are transported after they have been absorbed or administered directly into the bloodstream.Which response by the student indicates understanding of the process?

Correct AnswerverifiedShow Answer

Which action will slow the absorption of a drug?

Correct AnswerverifiedB

A nurse educator is teaching pharmacokinetics to the pharmacology class.What statement,made by a student,would show the class understands this term?

Correct AnswerverifiedShow Answer

What is an indicator of how long a drug will produce its effect in the body?

Correct AnswerverifiedShow Answer

What is not a barrier to distribution of medications?

Correct AnswerverifiedD

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D

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B

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D