Question 1

Suspending agent and some sugars can be used as viscosity imparters.

Accepted Answer

A)  True
B)  False
C)  none
D)  allE) B) and C)
F) B) and D)

Question 2

What should be the range of oil/water partition coefficient of any drug?

Accepted Answer

A)  1-2
B)  3-4
C)  2-3
D)  1-3E) B) and C)
F) C) and D)

Question 3

What is the pH range of the intestine?

Accepted Answer

A)  4-5
B)  1-3
C)  1-8
D)  5-8E) B) and D)
F) None of the above

Question 4

Which of the following will be an example of an organic suspending agent?

Accepted Answer

A)  CMC
B)  MC
C)  Acacia
D)  CarbowaxesE) B) and D)
F) C) and D)

Question 5

Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent.

Accepted Answer

A)  True
B)  False
C)  none
D)  allE) None of the above
F) C) and D) A

Question 6

Which one of these is an example of a strong acid drug?

Accepted Answer

A)  Diazepam
B)  Ibuprofen
C)  Cromolyn
D)  AspirinE) All of the above
F) C) and D)

Question 7

According to the pH-partition hypothesis which one of the given options doesn't govern the absorption?

Accepted Answer

A)  The molecular size of the drug
B)  PH at the absorption site
C)  Lipid solubility of unionized drugs
D)  Dissociation constantE) All of the above
F) A) and B)

Question 8

Example of a drug which has PKa > 11 is ________

Accepted Answer

A)  Cromolyn
B)  Imipramine
C)  Amitriptyline
D)  MecamylamineE) A) and B)
F) A) and C)

Question 9

Which one of these is not a mechanism of the working of surfactants?

Accepted Answer

A)  Promote wetting by increasing the effective surface area
B)  Helps in the dissolution of drug
C)  Better membrane contact of the drug
D)  Decrease membrane permeabilityE) A) and B)
F) None of the above D

Question 10

All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma.

Accepted Answer

A)  True
B)  False
C)  none
D)  allE) A) and B)
F) None of the above B

Question 11

Which of the following equations correct for Henderson-Hasselbach equation for weak bases?

Accepted Answer

A)  PH = pKa - log (Unionized drug concentration /Ionized drug concentration) 
B)  PH = pKa - log (Ionized drug concentration/ Unionized drug concentration) 
C)  PH = pKa + log (Ionized drug concentration/ Unionized drug concentration) 
D)  PH = pKa + log (Unionized drug concentration /Ionized drug concentration) E) None of the above
F) A) and D)

Question 12

Which one of these options is not one of the limitations of pH-partition theory?

Accepted Answer

A)  Presence if virtual membrane pH
B)  Absorption of ionized drugs
C)  Influence of GI surface area
D)  Dissolution rateE) B) and C)
F) A) and B)

Question 13

According to the pH-partition theory which form of the drug gets absorbed mostly?

Accepted Answer

A)  Hydrated form
B)  Aggregated form
C)  Ionised
D)  UnionisedE) A) and D)
F) B) and D)

Question 14

Heroin with pKa 7.8 will be in which form in intestinal pH?

Accepted Answer

A)  Ionized form mostly
B)  Unionized form mostly
C)  Half ionized and half no ionized
D)  Will form aggregateE) A) and B)
F) A) and C)

Question 15

Nitrazepam a weak base, will be in which form in the stomach?

Accepted Answer

A)  Ionized form mostly
B)  Non-ionized form mostly
C)  Half ionized and half no ionized
D)  Will form aggregateE) A) and D)
F) B) and D)

Question 16

Which one of these is not an example of a basic drug with pKa range 5-11?

Accepted Answer

A)  Cromolyn
B)  Imipramine
C)  Amitriptyline
D)  ChloroquineE) A) and D)
F) A) and B)

Question 17

What is the pH range of the stomach?

Accepted Answer

A)  1-4
B)  5-8
C)  1-3
D)  1-8E) A) and D)
F) A) and B)

Question 18

What helps the ionized drug molecules to pass through the cell membrane passively?

Accepted Answer

A)  Different pH
B)  Polar group
C)  Large lipophilic group
D)  HydrationE) C) and D)
F) B) and D)

Question 19

If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have less amount of drug.

Accepted Answer

A)  True
B)  False
C)  none
D)  allE) A) and B)
F) A) and C)

Question 20

The concentration of colorant does not affect the drug solubility.

Accepted Answer

A)  True
B)  False
C)  none
D)  allE) C) and D)
F) A) and C)

Exam 7: Drug Dissolution, Ph-Partition Theory, and Drug Forms

Suspending agent and some sugars can be used as viscosity imparters.

Correct AnswerverifiedShow Answer

What should be the range of oil/water partition coefficient of any drug?

Correct AnswerverifiedShow Answer

What is the pH range of the intestine?

Correct AnswerverifiedShow Answer

Which of the following will be an example of an organic suspending agent?

Correct AnswerverifiedShow Answer

Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent.

Correct AnswerverifiedA

Which one of these is an example of a strong acid drug?

Correct AnswerverifiedShow Answer

According to the pH-partition hypothesis which one of the given options doesn't govern the absorption?

Correct AnswerverifiedShow Answer

Example of a drug which has PKa > 11 is ________

Correct AnswerverifiedShow Answer

Which one of these is not a mechanism of the working of surfactants?

Correct AnswerverifiedD

All drugs which are weak acids or acidic in nature will be in a unionized form in the plasma.

Correct AnswerverifiedB

Which of the following equations correct for Henderson-Hasselbach equation for weak bases?

Correct AnswerverifiedShow Answer

Which one of these options is not one of the limitations of pH-partition theory?

Correct AnswerverifiedShow Answer

According to the pH-partition theory which form of the drug gets absorbed mostly?

Correct AnswerverifiedShow Answer

Heroin with pKa 7.8 will be in which form in intestinal pH?

Correct AnswerverifiedShow Answer

Nitrazepam a weak base, will be in which form in the stomach?

Correct AnswerverifiedShow Answer

Which one of these is not an example of a basic drug with pKa range 5-11?

Correct AnswerverifiedShow Answer

What is the pH range of the stomach?

Correct AnswerverifiedShow Answer

What helps the ionized drug molecules to pass through the cell membrane passively?

Correct AnswerverifiedShow Answer

If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have less amount of drug.

Correct AnswerverifiedShow Answer

The concentration of colorant does not affect the drug solubility.

Correct AnswerverifiedShow Answer

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A

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D

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B

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