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Fungal infections of the CNS are most commonly seen in


A) immunocompetent individuals.
B) young, healthy individuals.
C) AIDS patients.
D) newborns.

E) None of the above
F) A) and B)

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Which of the following protozoan(s) use antigenic switching to avoid the host immune system?


A) T. gondii
B) T. brucei
C) T. cruzi
D) T. brucei and T. cruzi

E) C) and D)
F) A) and D)

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D

All of the following are caused by prions EXCEPT


A) sheep scrapie.
B) kuru.
C) rabies.
D) bovine spongiform encephalopathy.

E) A) and C)
F) A) and B)

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A physician diagnoses a patient with Eastern equine encephalitis.All of the following pertain to the patient EXCEPT that he or she


A) most likely caught the virus from a bite from an infected mosquito.
B) was diagnosed by detecting an increase in antibody titer to the virus.
C) is infected with a neurotropic virus.
D) is infected with a rare disease.

E) B) and D)
F) A) and D)

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C

Which of the following is treated with antibiotics?


A) botulism
B) tetanus
C) streptococcal pneumonia
D) polio

E) None of the above
F) B) and C)

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CASE HISTORY In June,Mitch,a 47-year-old resident of Oklahoma,was admitted to the hospital with rapid onset of progressive dizziness,blurred vision,slurred speech,difficulty swallowing,and nausea.Findings on examination included absence of fever,drooping eyelids,facial paralysis,and impaired gag reflex.He developed breathing difficulties and required mechanical ventilation.The patient reported that during the 24 hours before onset of symptoms,he had eaten home-canned green beans and a stew containing roast beef and potatoes.Analysis of the patient's stool detected botulinum type a toxin,but no Clostridium botulinum organisms were found.The patient was hospitalized for 49 days,including 42 days on mechanical ventilation,before being discharged. Briefly describe the likely progress of Mitch's disease from exposure to hospitalization.Is antibiotic therapy likely to be useful in the treatment of Mitch's disease? Why or why not?

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It was likely consumption of f...

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The ________ collects data from the outside environment and communicates that information to the ________.

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peripheral...

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Arboviruses cause ________ and are transmitted by ________.


A) meningitis; bee stings
B) meningitis; mosquitoes
C) encephalitis; dog bites
D) encephalitis; mosquitoes

E) All of the above
F) B) and C)

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All of the following are true of polio EXCEPT


A) the portal of entry is ingestion of contaminated water.
B) most cases are severe and result in paralysis.
C) it replicates in the throat and small intestines.
D) the Sabin vaccine contains attenuated strains of the virus.

E) B) and D)
F) A) and B)

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A small proteinaceous infectious particle is known as a ________.

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Which of the images is the amebic form that infects humans? Which of the images is the amebic form that infects humans?   A)  A B)  B C)  C D)  none


A) A
B) B
C) C
D) none

E) C) and D)
F) None of the above

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Which of the following statements about rabies is FALSE?


A) It is caused by lyssavirus.
B) Rabies virus is a neurotropic virus.
C) Hydrophobia is associated with the disease.
D) There are three basic forms: encephalitic, paralytic, and atypical.

E) A) and D)
F) None of the above

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Explain the transmission,etiologies,and diagnosis of bacterial meningitis.

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Bacterial meningitis is considered a medical emergency.Patient history can provide clues,but laboratory results are needed for definitive diagnosis.Neisseria meningitidis,Streptococcus pneumoniae,and Haemophilus influenzae type b are the top causative agents of meningitis. Neisseria meningitidis affects people of all ages;however,it severely targets adolescents and young adults.It is transmitted from the nasopharynx of infected individuals.Diagnosis is based off clinical presentation,isolation of the bacteria from CSF,and/or blood and Gram stain of CSF. Streptococcus pneumoniae affects people of all ages and is transmitted via the respiratory tract.Diagnosis is based off clinical presentation,CSF analysis,bacterial culture,and Gram stain. Haemophilus influenzae affects unvaccinated adults and children and is transmitted from the upper respiratory tract.Diagnosis is based off clinical presentation,CSF analysis,blood culture,and Gram stain.

CASE HISTORY In June,Mitch,a 47-year-old resident of Oklahoma,was admitted to the hospital with rapid onset of progressive dizziness,blurred vision,slurred speech,difficulty swallowing,and nausea.Findings on examination included absence of fever,drooping eyelids,facial paralysis,and impaired gag reflex.He developed breathing difficulties and required mechanical ventilation.The patient reported that during the 24 hours before onset of symptoms,he had eaten home-canned green beans and a stew containing roast beef and potatoes.Analysis of the patient's stool detected botulinum type a toxin,but no Clostridium botulinum organisms were found.The patient was hospitalized for 49 days,including 42 days on mechanical ventilation,before being discharged. What are the risk factors for botulism like that in Mitch's case? How can this disease be prevented?

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Individual risk factors largely irreleva...

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Bacterial encephalitis and meningitis are difficult to treat because


A) no medications exist for treatment of these infections.
B) antibiotics damage nervous tissue.
C) many antibiotics cannot cross the blood-brain barrier.
D) it is very difficult to determine the causative microbe.

E) None of the above
F) A) and B)

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Initial treatment for tetanus in an unimmunized person with a puncture wound is


A) tetanus immune globulin.
B) tetanus toxoid.
C) penicillin.
D) debridement.

E) A) and D)
F) A) and C)

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Which of the following pairs is mismatched?


A) poliomyelitis - respiratory route
B) meningococcal meningitis - respiratory route
C) rabies - direct contact
D) listeriosis - ingestion

E) A) and B)
F) A) and C)

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A pathologist detects Negri bodies while examining a brain section taken at autopsy.What was the cause of death?


A) rabies
B) poliomyelitis
C) spongiform encephalopathy
D) West Nile encephalitis

E) A) and B)
F) A) and C)

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Microorganisms reach the CNS by all of the following EXCEPT


A) migrating to the CNS from distal sites.
B) toxins traveling along peripheral nerves.
C) infecting bone.
D) inhalation of the organism.

E) A) and C)
F) B) and C)

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Which of the following is true about CSF?


A) Inflammatory cells are found in both healthy and unhealthy CSF.
B) It helps to diagnose infections of the central nervous system.
C) The identification of PMNs in CSF indicates a viral infection.
D) CSF is collected via the placement of a shunt in the vertebral column.

E) C) and D)
F) None of the above

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