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Rigor mortis is caused by


A) Buildup of lactic acid
B) Lack of Ca2+
C) Depletion of glycogen
D) Lack of ATP
E) Deficient acetylcholine receptors

F) All of the above
G) B) and C)

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Which of the following is not a determinant of whole-muscle tension?


A) Number of muscle fibers contracting
B) Tension produced by each contracting fiber
C) Extent of motor unit recruitment
D) Frequency of motor neuron stimulation
E) Proportion of the muscle fibers in each motor unit that are contracting at any given time

F) None of the above
G) B) and E)

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Binding of ________ to myosin permits cross-bridge _____________ between actin and myosin.


A) ATP; attachment
B) ATP; detachment
C) Calcium; attachment
D) Calcium; detachment
E) Actin; detachment

F) A) and B)
G) B) and D)

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Rigor mortis occurs in a dead person because


A) ATP, which is necessary for the detachment of cross bridges, is not being formed
B) ATP, which is necessary for the formation of cross bridges, is not being formed
C) ATP, which is necessary for the formation of cross bridges, continues to be formed for several hours after death
D) Deterioration of muscle proteins prevents detachment of cross bridges
E) None of the choices are correct

F) A) and B)
G) A) and C)

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An action potential in the motor end plate rapidly spreads to the central portions of a muscle cell by means of the


A) Z lines
B) Sarcoplasmic reticulum
C) H zone
D) Transverse tubules
E) Pores in the plasma membrane

F) A) and E)
G) D) and E)

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Which of the following is not true regarding single-unit smooth-muscle cells? They


A) Have individual innervation of each cell
B) Have many gap junctions between cells
C) May have pacemaker activity
D) Respond to stretch by contracting
E) Have tone

F) C) and E)
G) D) and E)

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The removal of calcium ions from the cytosol of skeletal muscle causes


A) The myosin binding sites on actin to be uncovered by tropomyosin
B) Tropomyosin to change conformation and thereby move troponin molecules over cross-bridge binding sites
C) Troponin to change conformation and thereby expose cross-bridge binding sites
D) The myosin binding sites on actin to be covered by tropomyosin
E) None of the choices are correct

F) C) and E)
G) A) and E)

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During isotonic contraction of a skeletal-muscle fiber the


A) Sarcomeres shorten
B) A bands shorten
C) I bands shorten
D) Both sarcomeres shorten and I bands shorten are correct
E) Both A bands shorten and I bands shorten are correct

F) A) and E)
G) All of the above

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A large diameter is typical of which type of skeletal-muscle fibers?


A) Type I
B) Type II

C) A) and B)
D) undefined

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Which of the following statements regarding contraction in skeletal and smooth muscle is true?


A) In skeletal muscle, calcium ion mediates changes in thin filaments that lead to cross-bridge activity; in smooth muscle, calcium ion mediates changes in thick filaments that lead to cross-bridge activity
B) In skeletal muscle, calcium ion binds to a regulatory protein on thin filaments; in smooth muscle, calcium ion binds to a regulatory protein on thick filaments
C) In skeletal muscle, calcium ion binds to troponin; in smooth muscle, calcium ion binds to calmodulin
D) Both in skeletal muscle, calcium ion mediates changes in thin filaments that lead to cross-bridge activity; in smooth muscle, calcium ion mediates changes in thick filaments that lead to cross-bridge activity and in skeletal muscle, calcium ion binds to troponin; in smooth muscle, calcium ion binds to calmodulin are true
E) All of the choices are true

F) C) and E)
G) D) and E)

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All isotonic contractions begin and end as isometric contractions.

A) True
B) False

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The calcium-binding protein in smooth muscle is calmodulin.

A) True
B) False

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The energy for muscle contraction is provided by the hydrolysis of ATP.

A) True
B) False

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Myasthenia gravis


A) Is an autoimmune disease
B) Occurs when the motor neuron terminals cannot secrete enough acetylcholine to stimulate the motor end plate adequately
C) Can be treated with a drug that temporarily inhibits acetylcholinesterase
D) Both is an autoimmune disease and occurs when the motor neuron terminals cannot secrete enough acetylcholine to stimulate the motor end plate adequately are correct
E) Both is an autoimmune disease and can be treated with a drug that temporarily inhibits acetylcholinesterase are correct

F) A) and C)
G) B) and D)

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Which of the following choices gives the correct sequence of events following the depolarization of transverse tubules in excitation-contraction coupling in cardiac muscle?


A) Calcium release into sarcoplasm, calcium ion influx through sarcolemma, actin and myosin attach, thin myofilaments slide toward the middle of sarcomeres
B) Actin and myosin attach, thin myofilaments slide toward the middle of sarcomeres, calcium release into sarcoplasm
C) Calcium release into sarcoplasm, actin and myosin attach, calcium ion influx through sarcolemma, thin myofilaments slide toward the middle of sarcomeres
D) Calcium release into sarcoplasm, actin and myosin attach, thin myofilaments slide toward the middle of sarcomeres, calcium ion influx through sarcolemma
E) Calcium ion influx through sarcolemma, calcium release into sarcoplasm, actin and myosin attach, thin myofilaments slide toward the middle of sarcomeres

F) A) and B)
G) A) and E)

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Nervous stimulation of skeletal muscle is always excitatory,whereas nervous stimulation of smooth muscle may be excitatory or inhibitory.

A) True
B) False

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Olympic speed (ice) skaters have large,muscular legs that are unusual in that the left leg is generally even larger in diameter than the right.This is an example of


A) Disuse atrophy of the right leg
B) Hypertrophy of fast-glycolytic muscle fibers as a result of exercise
C) An increase in the number of fast muscle fibers as a result of exercise
D) Both disuse atrophy of the right leg and hypertrophy of fast-glycolytic muscle fibers as a result of exercise
E) Both hypertrophy of fast-glycolytic muscle fibers as a result of exercise and an increase in the number of fast muscle fibers as a result of exercise

F) A) and E)
G) B) and E)

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Excitation-contraction coupling refers to the binding of energized myosin to actin.

A) True
B) False

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During isometric contraction of a skeletal-muscle fiber,tension increases but the fiber length stays the same.

A) True
B) False

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In cardiac muscle contractile cells the release of calcium through L-type calcium channels depolarizes the sarcoplasmic reticulum and inhibits the release of any additional calcium necessary for excitation-contraction coupling.

A) True
B) False

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