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A 31-year-old man suffering from food poisoning is having severe vomiting for the last 2 days. His blood gas and serum electrolyte analyses revealed the following: pH of 7.60, PaCO2 of 49 mm Hg, an HCO3- of 47 mEq/L, a base excess (BE) of +20 mEq/L, a serum K+ of 2.5 mEq/L, and a serum of Cl- of 92 mEq/L. How would the respiratory therapist assess his acid-base condition? 1) Severe hyperventilation 2) Metabolic alkalosis 3) Adequate compensatory response 4) Minimal hypoventilation


A) 1, 2, and 3 only
B) 2 and 4 only
C) 3 only
D) 2, 3, and 4 only

E) All of the above
F) B) and C)

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A patient who has fully compensated respiratory acidosis becomes severely hypoxic. If her lungs are not too severely compromised, what might her gases now appear to be?


A) Fully compensated metabolic acidosis
B) Fully compensated metabolic alkalosis
C) Fully compensated respiratory alkalosis
D) No change

E) All of the above
F) A) and C)

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Which of the following is a volatile acid of physiologic significance?


A) Hydrochloric
B) Carbonic
C) Phosphoric
D) Lactic

E) A) and B)
F) A) and C)

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Which of the following statements about the equilibrium constant of an acid is true?


A) The equilibrium constant of a weak acid is large.
B) The equilibrium constant of a strong acid is small.
C) The equilibrium constant of a weak acid is small.
D) The more an acid ionizes, the smaller is the equilibrium constant.

E) B) and C)
F) A) and D)

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A patient with a measured plasma HCO3- concentration of 24 mmol/L has an episode of acute hypoventilation, with the PCO2 rising from 40 to 70 mm Hg. What do you predict will happen acutely to the plasma HCO3- concentration?


A) HCO3- will remain unchanged.
B) HCO3- will rise to approximately 27 to 28 mmol/L.
C) HCO3- will fall to approximately 20 to 21 mmol/L.
D) HCO3- will rise to approximately 54 to 55 mmol/L.

E) A) and C)
F) B) and D)

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What is the sum of all blood buffers in 1 L of blood?


A) Buffer base
B) Base excess
C) Standard bicarbonate
D) Base deficit

E) A) and C)
F) C) and D)

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A patient has a pH of 7.49. How would you describe this?


A) Acidemia
B) Alkalemia
C) Not sufficient information to determine
D) Normal acid-base status

E) B) and C)
F) A) and D)

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Based on the following ABG results, what is the most likely acid-base diagnosis? pH = 7.08, PCO2 = 39 mm Hg, HCO3- = 11.8 mEq/L


A) Acute metabolic acidosis
B) Acute respiratory acidosis
C) Partially compensated metabolic acidosis
D) Partially compensated respiratory acidosis

E) B) and C)
F) B) and D)

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Which of the following clinical findings would you expect in a fully compensated respiratory acidosis? 1) Elevated HCO3- 2) pH below 7.35 3) pH between 7.35 and 7.39 4) Elevated PO2


A) 1 and 3 only
B) 2 and 3 only
C) 2 and 4 only
D) 1, 3, and 4 only

E) C) and D)
F) A) and B)

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What effect does hyperventilation have on HCO3- recovery in the kidneys?


A) Less H+ excretion, greater HCO3- loss
B) No effect as these involve two independent systems.
C) Vicious cycle of worsening alkalemia as hyperventilation stimulates increased HCO3- retention.
D) Escalating retention of other buffer bases along with HCO3-.

E) A) and C)
F) A) and B)

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What is a normal response of the body to a failure in one component of the acid-base regulatory mechanism?


A) Autoregulation
B) Compensation
C) Correction
D) Homeostasis

E) A) and B)
F) All of the above

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If the blood PCO2 is high, the kidneys will do which of the following?


A) Excrete more H+ and reabsorb more HCO3-.
B) Excrete less H+ and reabsorb more HCO3-.
C) Excrete less H+ and reabsorb less HCO3-.
D) Excrete more H+ and reabsorb less HCO3-.

E) A) and D)
F) B) and C)

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Which of the following acts as the "first-line" or immediate defense against the accumulation of H+ ions?


A) Blood buffer system
B) GI tract
C) Renal system
D) Respiratory system

E) None of the above
F) A) and D)

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Using the Henderson-Hasselbalch equation, determine the accuracy of the gas below. To be considered accurate, it must be within 0.03 pH unit. pH = 7.35, PCO2 = 77 mm Hg, HCO3- = 41 mEq/L


A) This gas is completely accurate.
B) This gas is accurate as the calculated pH is 7.32.
C) This gas is accurate as the calculated pH is 7.38.
D) This gas is inaccurate according to the H-H equation.

E) A) and B)
F) C) and D)

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In a patient with partially compensated respiratory alkalosis, which of the following blood gas abnormalities would you expect to encounter? 1) Decreased pH 2) Decreased HCO3- 3) Decreased PCO2 4) Increased pH


A) 1, 2, and 4
B) 1 and 3
C) 3 only
D) 2, 3, and 4

E) C) and D)
F) A) and C)

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What factor would limit the ability of the H2CO3/HCO3- buffer system to perform efficiently?


A) Temperature rise of more than 3° C
B) Inadequate amount of 2,3-DPG in the blood
C) Increased production of nonvolatile acids
D) Lungs failing to excrete adequate levels of CO2

E) A) and B)
F) A) and C)

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Which of the following is/are cause(s) of metabolic alkalosis? 1) Diuretics 2) Hyperkalemia 3) Hypochloremia 4) Vomiting


A) 1, 3, and 4 only
B) 2 and 3 only
C) 1, 2, and 4 only
D) 2 only

E) All of the above
F) A) and B)

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Based on the following ABG results, what is the most likely acid-base diagnosis? pH = 7.38, PCO2 = 21 mm Hg, HCO3- = 11.7 mEq/L


A) Acute metabolic acidosis
B) Fully compensated metabolic acidosis
C) Partially compensated metabolic acidosis
D) Fully compensated respiratory alkalosis

E) None of the above
F) C) and D)

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An ABG result shows pH of 7.35, PaCO2 of 30 mm Hg, and HCO3- of 18 mEq/L. Which of the following is the patient's most likely primary disorder?


A) Metabolic acidosis
B) Metabolic alkalosis
C) Respiratory acidosis
D) Respiratory alkalosis

E) A) and B)
F) None of the above

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Metabolic acidosis may be caused by: 1) an increase in fixed (nonvolatile) acids. 2) an increase in blood carbon dioxide (CO2) . 3) excessive loss of bicarbonate (HCO3-) .


A) 1 only
B) 1 and 2 only
C) 1, 2, and 3
D) 1 and 3 only

E) A) and D)
F) C) and D)

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